Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4615301 | 0.89 | NR1H4 (0.47) | NR1H4FFAR1KDM4EPOLBMITF | |
| SCHEMBL16355781 | 0.80 | MAPT (0.43) | POLBSMN1; SMN2KMT2A | |
| SCHEMBL4612953 | 0.77 | SMN1; SMN2 (0.51) | KDM4ESMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL1688815 | 0.76 | POLB (0.47) | KDM4EPOLBSMN1; SMN2RAB9AMEN1 | |
| SCHEMBL11573216 | 0.75 | NR1H4 (0.45) | NR1H4FFAR1KDM4EPOLBMITF | |
| SCHEMBL21554546 | 0.74 | CA2 (0.50) | NR1H4FFAR1KDM4EPOLBHSD17B10 | |
| SCHEMBL9285787 | 0.74 | MITF (0.45) | NR1H4FFAR1KDM4EPOLBMITF | |
| SCHEMBL9273630 | 0.74 | MALT1 (0.47) | NR1H4FFAR1KDM4EPOLBMITF | |
| SCHEMBL13611310 | 0.74 | FFAR1 (0.59) | NR1H4FFAR1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL977842 | 0.74 | PTGDR2 (0.60) | NR1H4FFAR1KDM4EPOLBMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192132-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1192135-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076970-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |
| WO-2000076971-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |