Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12491199 | 0.85 | CHRM2 (0.55) | ALDH1A1L3MBTL1 | |
| SCHEMBL27517827 | 0.76 | KCNH2 (0.48) | KCNH2NPC1RAB9APARP10MMP13 | |
| SCHEMBL16874617 | 0.74 | TP53 (0.47) | KCNH2NPC1RAB9AHTTHRH3 | |
| SCHEMBL8209192 | 0.73 | MMP13 (0.49) | KCNH2NPC1RAB9APARP10MMP13 | |
| SCHEMBL6628834 | 0.73 | ADAM17 (0.62) | RAB9AMMP13SMN1; SMN2LMNA | |
| SCHEMBL10892909 | 0.71 | SIGMAR1 (0.47) | L3MBTL1 | |
| SCHEMBL2714652 | 0.71 | KCNH2 (0.55) | KCNH2NPC1RAB9APARP10 | |
| SCHEMBL2713220 | 0.71 | KCNH2 (0.55) | KCNH2NPC1RAB9APARP10 | |
| SCHEMBL2712695 | 0.71 | KCNH2 (0.55) | KCNH2NPC1RAB9APARP10 | |
| SCHEMBL27037680 | 0.70 | MRGPRX4 (0.57) | KCNH2NPC1RAB9AHTTHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027332-A1 | NOVEL LACTAM METALLOPROTEASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999018074-A1 | NOVEL LACTAM METALLOPROTEASE INHIBITORS | Britol-Myers Squibb Pharma Company (US) | 1999-04-15 | — | — | WO | disclosed |