Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 3/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31477970 | 0.72 | KMT2A (0.52) | KCNA5ALDH1A1L3MBTL1 | |
| SCHEMBL6288702 | 0.69 | KCNA5 (0.53) | GPR139KCNA5EGLN1CNR1CNR2 | |
| SCHEMBL24387800 | 0.68 | KCNA5 (0.52) | GPR139KCNA5EGLN1CNR1CNR2 | |
| SCHEMBL6166510 | 0.68 | KMT2A (0.47) | GPR139CNR1CNR2ALDH1A1HTT | |
| SCHEMBL7361912 | 0.67 | FFAR1 (0.53) | GPR139KCNA5CNR1CNR2HTT | |
| SCHEMBL7365375 | 0.66 | F10 (0.56) | ALDH1A1 | |
| SCHEMBL9779966 | 0.66 | ALDH1A1 (0.58) | EGLN1ALDH1A1HTTL3MBTL1LMNA | |
| SCHEMBL7116483 | 0.66 | GSK3B (0.49) | GPR139KCNA5CNR1CNR2ALDH1A1 | |
| SCHEMBL7363315 | 0.65 | F10 (0.60) | KCNA5 | |
| SCHEMBL7686273 | 0.65 | KCNA5 (0.47) | GPR139KCNA5EGLN1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892780-A1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997030971-A1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |