Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7367006 | 0.68 | SMN1; SMN2 (0.32) | SMN1; SMN2KMT2AHTTHDAC8ALDH1A1 | |
| Oxalic Acid SCHEMBL467154 | 0.67 | DRD4 (0.40) | KMT2AALDH1A1 | |
| Oxalic Acid SCHEMBL467153 | 0.67 | DRD4 (0.40) | KMT2AALDH1A1 | |
| SCHEMBL5449384 | 0.65 | ATM (0.54) | SMN1; SMN2KMT2AHTTALDH1A1CES2 | |
| SCHEMBL5449388 | 0.65 | ATM (0.54) | SMN1; SMN2KMT2AHTTALDH1A1CES2 | |
| SCHEMBL14604957 | 0.65 | ATM (0.54) | SMN1; SMN2KMT2AHTTALDH1A1CES2 | |
| SCHEMBL9875097 | 0.62 | ALDH1A1 (0.40) | SMN1; SMN2KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL5450434 | 0.62 | PTGS2 (0.53) | SMN1; SMN2KMT2AHTTHDAC8ALDH1A1 | |
| SCHEMBL5450436 | 0.62 | PTGS2 (0.53) | SMN1; SMN2KMT2AHTTHDAC8ALDH1A1 | |
| SCHEMBL27348181 | 0.61 | KDM4E (0.57) | SMN1; SMN2KMT2AHTTHDAC8CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993019047-A1 | TETRAHIDROPYRIDINYL (3/4) SUBSTITUED OXIMES HAVING SIGMA RECEPTOR AFFINITY AND THEIR USE IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM CONDITIONS | WARNER-LAMBERT COMPANY (US) | 1993-09-30 | — | — | WO | claimed |
| WO-1993019047-A1 | TETRAHIDROPYRIDINYL (3/4) SUBSTITUED OXIMES HAVING SIGMA RECEPTOR AFFINITY AND THEIR USE IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM CONDITIONS | WARNER-LAMBERT COMPANY (US) | 1993-09-30 | — | — | WO | disclosed |