Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364039 | 0.91 | ADORA1 (0.54) | ADORA1HSD17B10SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7373031 | 0.84 | ADORA1 (0.48) | ADORA1EGFRMAPTKMT2AIGF1R | |
| SCHEMBL7368729 | 0.83 | ADORA1 (0.52) | ADORA1MEN1KMT2AKDM4EIGF1R | |
| SCHEMBL7365823 | 0.82 | ADORA1 (0.50) | ADORA1 | |
| SCHEMBL7364802 | 0.81 | ADORA1 (0.52) | ADORA1SMN1; SMN2MEN1MAPTKMT2A | |
| SCHEMBL8810012 | 0.81 | ADORA1 (0.73) | ADORA1HSD17B10EGFRSMN1; SMN2KDM4E | |
| SCHEMBL7370080 | 0.79 | ADORA1 (0.48) | ADORA1MEN1CYP1A2KMT2AIGF1R | |
| SCHEMBL7365508 | 0.79 | ADORA1 (0.47) | ADORA1MEN1KMT2AIGF1R | |
| SCHEMBL4240548 | 0.77 | FGFR1 (0.43) | ADORA1MAPTKDM4EIGF1R | |
| SCHEMBL5671140 | 0.77 | GRM2 (0.42) | ADORA1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |