Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3616432 | 0.89 | ADORA1 (0.59) | ADORA1MEN1KMT2AIGF1RPOLB | |
| SCHEMBL7364039 | 0.83 | ADORA1 (0.54) | ADORA1MEN1KMT2AIGF1RPOLB | |
| SCHEMBL7365823 | 0.82 | ADORA1 (0.50) | ADORA1POLBPTGS1PTGS2ADORA2A | |
| SCHEMBL7368729 | 0.80 | ADORA1 (0.52) | ADORA1MEN1KMT2AIGF1RPOLB | |
| SCHEMBL7370080 | 0.80 | ADORA1 (0.48) | ADORA1MEN1KMT2AIGF1RPOLB | |
| SCHEMBL7362339 | 0.79 | ADORA1 (0.60) | ADORA1MEN1KMT2AIGF1R | |
| SCHEMBL7364802 | 0.78 | ADORA1 (0.52) | ADORA1MEN1KMT2AIGF1RMAPK1 | |
| SCHEMBL7373031 | 0.76 | ADORA1 (0.48) | ADORA1KMT2AIGF1RPTGS1ADORA2A | |
| SCHEMBL7291999 | 0.73 | ADORA1 (0.63) | ADORA1MEN1KMT2AIGF1RPOLB | |
| SCHEMBL4240548 | 0.72 | FGFR1 (0.43) | ADORA1IGF1RMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |