Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7488213 | 0.88 | ADORA1 (0.66) | ADORA1MAPK1KDM4EMEN1KMT2A | |
| SCHEMBL7364039 | 0.85 | ADORA1 (0.54) | ADORA1MAPK1KDM4EMEN1KMT2A | |
| SCHEMBL7368729 | 0.82 | ADORA1 (0.52) | ADORA1MAPK1KDM4EMEN1KMT2A | |
| SCHEMBL7365823 | 0.81 | ADORA1 (0.50) | ADORA1HDAC1 | |
| SCHEMBL7362339 | 0.81 | ADORA1 (0.60) | ADORA1KDM4EMEN1KMT2AIGF1R | |
| SCHEMBL7373031 | 0.79 | ADORA1 (0.48) | ADORA1MAPK1KMT2AALDH1A1HTT | |
| SCHEMBL7370080 | 0.78 | ADORA1 (0.48) | ADORA1MAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL7365508 | 0.78 | ADORA1 (0.47) | ADORA1MAPK1MEN1KMT2AIGF1R | |
| SCHEMBL11403000 | 0.76 | HTT (0.59) | KDM4EMEN1KMT2AALDH1A1ADRB2 | |
| SCHEMBL8639797 | 0.75 | ADORA1 (0.72) | ADORA1MAPK1KDM4EHTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |