Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364039 | 0.88 | ADORA1 (0.54) | ADORA1IGF1RMAPK1MEN1KMT2A | |
| SCHEMBL7301059 | 0.87 | ADORA1 (0.67) | ADORA1IGF1RMAPK1MEN1KMT2A | |
| SCHEMBL7365823 | 0.83 | ADORA1 (0.50) | ADORA1POLBPTGDR2PDE4APDE4B | |
| SCHEMBL7362339 | 0.83 | ADORA1 (0.60) | ADORA1IGF1RMEN1KMT2AKDM4E | |
| SCHEMBL7364802 | 0.82 | ADORA1 (0.52) | ADORA1IGF1RMAPK1MEN1KMT2A | |
| SCHEMBL7373031 | 0.81 | ADORA1 (0.48) | ADORA1IGF1RMAPK1KMT2AHTT | |
| SCHEMBL7370080 | 0.81 | ADORA1 (0.48) | ADORA1IGF1RMAPK1MEN1KMT2A | |
| SCHEMBL7365508 | 0.80 | ADORA1 (0.47) | ADORA1IGF1RMAPK1MEN1KMT2A | |
| SCHEMBL7292709 | 0.77 | ADORA1 (0.69) | ADORA1IGF1RMAPK1HTTTSHR | |
| SCHEMBL4240548 | 0.77 | FGFR1 (0.43) | ADORA1IGF1RMAPK1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |