Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 3/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 2/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364039 | 0.86 | ADORA1 (0.54) | ADORA1POLBPDE4APDE4BPDE4C | |
| SCHEMBL7368729 | 0.83 | ADORA1 (0.52) | ADORA1ADORA2APOLBPTGDR2PDE4A | |
| SCHEMBL7370080 | 0.83 | ADORA1 (0.48) | ADORA1POLB | |
| SCHEMBL7365508 | 0.82 | ADORA1 (0.47) | ADORA1ADORA2AHDAC1METPOLB | |
| SCHEMBL7362339 | 0.82 | ADORA1 (0.60) | ADORA1 | |
| SCHEMBL7304113 | 0.82 | ADORA1 (0.68) | ADORA1POLBPTGDR2PDE4APDE4B | |
| SCHEMBL7364802 | 0.81 | ADORA1 (0.52) | ADORA1HDAC1 | |
| SCHEMBL7291999 | 0.80 | ADORA1 (0.63) | ADORA1ADORA2AHDAC1POLBPTGDR2 | |
| SCHEMBL7373031 | 0.79 | ADORA1 (0.48) | ADORA1ADORA2APTGS1 | |
| SCHEMBL28158481 | 0.77 | HDAC1 (0.61) | ADORA1ADORA2AHDAC1METIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |