Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | ARG1 | P05089 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28411111 | 0.84 | SMN1; SMN2 (0.37) | ADORA2BARG1NPC1KMT2AESR1 | |
| SCHEMBL4314338 | 0.77 | SMN1; SMN2 (0.39) | ALDH1A1ARG1NPC1KMT2ASMN1; SMN2 | |
| SCHEMBL3810263 | 0.77 | ALDH1A1 (0.35) | ALDH1A1ARG1NPC1TSHRKDM4E | |
| SCHEMBL30554012 | 0.76 | KMT2A (0.43) | ALDH1A1NPC1KMT2AKDM4ERAB9A | |
| SCHEMBL2719494 | 0.74 | PPARG (0.51) | ALDH1A1NPC1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL31210326 | 0.74 | ARG1 (0.39) | ALDH1A1ARG1ESR1SMN1; SMN2RAB9A | |
| SCHEMBL27845254 | 0.74 | TLR8 (0.42) | ALDH1A1ARG1KMT2ASMN1; SMN2 | |
| SCHEMBL4333586 | 0.72 | SMN1; SMN2 (0.33) | ALDH1A1ARG1NPC1KDM4EESR1 | |
| SCHEMBL5616672 | 0.72 | — | — | |
| SCHEMBL5141262 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5789406-A | Indeno 1,2-E!pyrazine-4-ones, their preparation and the medicaments containing them | RHONE-POULENC RORER S.A. (FR) | 1998-08-04 | — | — | US | disclosed |
| US-5672705-A | ANTIISCHEMIC AGENTS TREATING NERVOUS SYSTEM DISORDERS, HUNTINGTON' DISEASE, ALZHEIMER'S DISEASE, PARKINSON'S DISEASE | RHONE-POULENC RORER S.A. (FR) | 1997-09-30 | — | — | US | disclosed |
| EP-0726900-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | Aventis Pharma S.A. (FR) | 1996-08-21 | — | — | EP | disclosed |
| WO-1995012594-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | RHONE-POULENC RORER S.A. (FR) | 1995-05-11 | — | — | WO | disclosed |