Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ARG1 | P05089 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | ALPI | P09923 | 1/20 | 0.31 |
| ▸ | ALPG | P10696 | 1/20 | 0.31 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4327360 | 0.85 | HTT (0.33) | SMN1; SMN2ALDH1A1NPC1RAB9AARG1 | |
| SCHEMBL4314338 | 0.80 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1NPC1RAB9AARG1 | |
| SCHEMBL31210326 | 0.77 | ARG1 (0.39) | SMN1; SMN2ALDH1A1RAB9AARG1TLR8 | |
| SCHEMBL27845254 | 0.77 | TLR8 (0.42) | SMN1; SMN2ALDH1A1ARG1TLR8 | |
| SCHEMBL3810263 | 0.77 | ALDH1A1 (0.35) | SMN1; SMN2ALDH1A1NPC1RAB9AARG1 | |
| SCHEMBL7362579 | 0.72 | ALDH1A1 (0.33) | SMN1; SMN2ALDH1A1NPC1RAB9AARG1 | |
| SCHEMBL18839651 | 0.71 | KDM4E (0.44) | SMN1; SMN2ALDH1A1NPC1MAPTKDM4E | |
| SCHEMBL28205879 | 0.70 | CYP11B1 (0.42) | SMN1; SMN2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL4325015 | 0.70 | SIRT2 (0.38) | ALDH1A1ARG1CDK8 | |
| SCHEMBL3313595 | 0.70 | ALDH1A1 (0.59) | SMN1; SMN2ALDH1A1NPC1RAB9AFDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009141386-A1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-11-26 | — | — | WO | disclosed |