Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6134300 | 0.81 | GRM5 (0.47) | GRM5AKR1B1HTR6AGTR1 | |
| SCHEMBL7366863 | 0.80 | HTR6 (0.46) | GRM5KCNH2AKR1B1PTGDR2HTR6 | |
| SCHEMBL7372249 | 0.77 | GRM5 (0.46) | GRM5KCNH2AKR1B1ALDH1A1KMT2A | |
| SCHEMBL7364220 | 0.76 | HTR2A (0.40) | KCNH2AKR1B1PTGDR2HTR6PKM | |
| SCHEMBL7368039 | 0.75 | GRM5 (0.41) | GRM5KCNH2AKR1B1HTR6PKM | |
| SCHEMBL7367382 | 0.75 | CA12 (0.43) | GRM5KCNH2AKR1B1HTT | |
| SCHEMBL10354233 | 0.74 | HTR6 (0.62) | AKR1B1HTR6KDM4EPKMAGTR1 | |
| SCHEMBL7366907 | 0.72 | CA12 (0.51) | GRM5 | |
| SCHEMBL7449426 | 0.72 | HTR6 (0.40) | GRM5PTGDR2HTR6KDM4EHSD17B10 | |
| SCHEMBL7301533 | 0.72 | GAA (0.53) | AKR1B1HTR6KDM4EPKMAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |