Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.49 |
| ▸ | PPARA | Q07869 | 4/20 | 0.49 |
| ▸ | PPARD | Q03181 | 3/20 | 0.49 |
| ▸ | MME | P08473 | 2/20 | 0.46 |
| ▸ | ECE1 | P42892 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10790695 | 0.90 | MME (0.50) | MMEECE1HRH4ACEMEN1 | |
| SCHEMBL7368050 | 0.90 | MME (0.50) | MMEECE1HRH4ACEMEN1 | |
| SCHEMBL10794359 | 0.89 | KDM4E (0.47) | MMEECE1HRH4ACEHTT | |
| SCHEMBL7362721 | 0.85 | MME (0.44) | MMEECE1HRH4ACEKMT2A | |
| SCHEMBL7316396 | 0.80 | MME (0.53) | PPARGMMEECE1HRH4ACE | |
| SCHEMBL10790828 | 0.79 | MME (0.52) | PPARGMMEECE1HRH4ACE | |
| SCHEMBL7366217 | 0.77 | LTA4H (0.44) | MMEECE1HRH4ACEMEN1 | |
| SCHEMBL10789536 | 0.76 | MME (0.49) | MMEECE1HRH4ACE | |
| SCHEMBL7318461 | 0.76 | ACE (0.70) | MMEECE1ACE | |
| SCHEMBL7367811 | 0.76 | ACE (0.70) | MMEECE1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0117429-B1 | PHOSPHOROUS CONTAINING COMPOUNDS AS INHIBITORS OF ENKEPHALINASES | SCHERING CORPORATION (US) | 1987-09-02 | — | — | EP | claimed |
| EP-0117429-A1 | Phosphorous containing compounds as inhibitors of enkephalinases | SCHERING CORPORATION (US) | 1984-09-05 | — | — | EP | claimed |
| EP-0117429-B1 | PHOSPHOROUS CONTAINING COMPOUNDS AS INHIBITORS OF ENKEPHALINASES | SCHERING CORPORATION (US) | 1987-09-02 | — | — | EP | disclosed |
| EP-0117429-A1 | Phosphorous containing compounds as inhibitors of enkephalinases | SCHERING CORPORATION (US) | 1984-09-05 | — | — | EP | disclosed |