Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.50 |
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | PKM | P14618 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | TDO2 | P48775 | 2/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362558 | 0.86 | KMT2A (0.51) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL7362871 | 0.80 | PDE4D (0.57) | KMT2AMEN1MAPTLMNAIDO1 | |
| SCHEMBL7370628 | 0.77 | PDE4A (0.52) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL7369477 | 0.75 | MEN1 (0.63) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL7367868 | 0.75 | PDE4A (0.55) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL7369609 | 0.75 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL7368635 | 0.74 | PDE4A (0.63) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL7365402 | 0.73 | PDE4A (0.73) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL1251253 | 0.73 | NPSR1 (0.67) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL1251237 | 0.73 | PARP1 (0.53) | ALDH1A1KMT2AMEN1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |