Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 10/20 | 0.57 |
| ▸ | PDE4A | P27815 | 10/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | GUSB | P08236 | 1/20 | 0.46 |
| ▸ | TOP1 | P11387 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366219 | 0.91 | PDE4D (0.58) | PDE4DPDE4APDE4CPDE4BMAPT | |
| SCHEMBL7362558 | 0.80 | KMT2A (0.51) | MAPTIDO1LMNAMEN1KMT2A | |
| SCHEMBL7362865 | 0.80 | ALDH1A1 (0.51) | MAPTIDO1LMNAMEN1KMT2A | |
| SCHEMBL7370628 | 0.80 | PDE4A (0.52) | PDE4DPDE4APDE4CPDE4BMAPT | |
| SCHEMBL1249841 | 0.80 | AURKA (0.54) | PDE4DPDE4APDE4CPDE4BMAPT | |
| SCHEMBL7366347 | 0.80 | PARP1 (0.46) | PDE4DPDE4APDE4CPDE4BMAPT | |
| SCHEMBL1251253 | 0.79 | NPSR1 (0.67) | MAPTHPGDIDO1MEN1KMT2A | |
| SCHEMBL5378145 | 0.78 | MAPT (0.81) | PDE4DPDE4APDE4CMAPTHPGD | |
| SCHEMBL1252689 | 0.77 | PARP1 (0.43) | PDE4DPDE4APDE4CPDE4BMAPT | |
| SCHEMBL9169239 | 0.77 | PIM1 (0.55) | MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-B1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX INC (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |