Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 12/20 | 0.50 |
| ▸ | MEN1 | O00255 | 11/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 13/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369609 | 0.89 | ALDH1A1 (0.46) | KMT2AMEN1SMN1; SMN2PDE4APDE4D | |
| SCHEMBL9382135 | 0.84 | PDE4A (0.55) | KMT2AMEN1SMN1; SMN2PDE4APDE4D | |
| SCHEMBL7369501 | 0.83 | PDE4A (0.63) | PDE4APDE4DPDE4BPDE4CMAPT | |
| SCHEMBL7364352 | 0.82 | KMT2A (0.48) | KMT2AMEN1SMN1; SMN2PDE4APDE4D | |
| SCHEMBL7367215 | 0.81 | PDE4A (0.63) | KMT2AMEN1SMN1; SMN2PDE4APDE4D | |
| SCHEMBL7362856 | 0.80 | PDE4A (0.73) | KMT2AMEN1SMN1; SMN2PDE4APDE4D | |
| SCHEMBL7370561 | 0.80 | L3MBTL1 (0.47) | PDE4APDE4DPDE4BPDE4CMAPT | |
| SCHEMBL7366444 | 0.78 | PDE4A (0.59) | KMT2AMEN1SMN1; SMN2PDE4APDE4D | |
| SCHEMBL7369403 | 0.78 | KDM4E (0.44) | SMN1; SMN2PDE4AMAPTALDH1A1KDM4E | |
| SCHEMBL7362558 | 0.76 | KMT2A (0.51) | KMT2AMEN1SMN1; SMN2MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |