Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | COMT | P21964 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 4/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370597 | 0.90 | L3MBTL1 (0.50) | L3MBTL1ADORA1COMTMAPTALDH1A1 | |
| SCHEMBL7369331 | 0.86 | SRC (0.46) | L3MBTL1ADORA1MAPTALDH1A1KAT2B | |
| SCHEMBL7369486 | 0.85 | KAT2B (0.49) | L3MBTL1ADORA1MAPTKAT2BPOLB | |
| SCHEMBL7362432 | 0.84 | MKNK1 (0.44) | L3MBTL1ADORA1MAPTKAT2BPOLB | |
| SCHEMBL7366633 | 0.82 | NCOA1 (0.46) | L3MBTL1ADORA1MAPTALDH1A1TACR1 | |
| SCHEMBL7363887 | 0.82 | KAT2B (0.52) | L3MBTL1ADORA1MAPTALDH1A1KAT2B | |
| SCHEMBL7363890 | 0.80 | PDE4A (0.61) | ADORA1MAPTCYP2C9CYP2C19PDE4A | |
| SCHEMBL8694519 | 0.80 | PDE4A (0.45) | L3MBTL1ADORA1MAPTALDH1A1CYP2C9 | |
| SCHEMBL7363024 | 0.80 | KMT2A (0.50) | L3MBTL1MAPTALDH1A1CYP2C19RAB9A | |
| SCHEMBL7370618 | 0.79 | RAB9A (0.51) | L3MBTL1ADORA1MAPTALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716954-A | ANTIINFLAMMATORY AGENT, ANTIHISTAMINES, IMMUNOSUPPRESSION,AUTOIMMUNE DISEASES | SYNTEX U.S.A. INC. (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |