Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.44 |
| ▸ | QPCT | Q16769 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.38 |
| ▸ | HRH2 | P25021 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360003 | 0.79 | P2RX7 (0.61) | NAMPTP2RX7QPCTHRH4HRH2 | |
| SCHEMBL7363206 | 0.78 | ALDH1A1 (0.43) | P2RX7KDM4ELMNACYP1A2POLB | |
| SCHEMBL8622511 | 0.77 | P2RX7 (0.69) | P2RX7LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7361546 | 0.74 | P2RX7 (0.40) | P2RX7HTT | |
| SCHEMBL7350535 | 0.74 | NAMPT (0.62) | NAMPTP2RX7QPCTHRH4HRH2 | |
| SCHEMBL7423091 | 0.71 | NAMPT (0.59) | NAMPTP2RX7QPCTHRH4HRH2 | |
| SCHEMBL9148294 | 0.70 | HRH4 (0.50) | NAMPTQPCTHRH4HRH2 | |
| SCHEMBL9838248 | 0.69 | NAMPT (0.57) | NAMPTP2RX7QPCTHRH4HRH2 | |
| SCHEMBL7424829 | 0.68 | HRH4 (0.53) | NAMPTQPCTHRH4HRH2 | |
| SCHEMBL7363204 | 0.68 | P2RX7 (0.42) | P2RX7LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741708-A1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | PHARMACIA & UPJOHN COMPANY (US) | 1996-11-13 | — | — | EP | claimed |
| WO-1995020579-A1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-03 | — | — | WO | claimed |