Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | TACR3 | P29371 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363327 | 1.00 | VNN1 (0.35) | VNN1HDAC3NCOR2MAPKAPK2HDAC1 | |
| SCHEMBL8439682 | 0.85 | VNN1 (0.36) | VNN1HDAC3NCOR2MAPKAPK2HDAC1 | |
| SCHEMBL7358018 | 0.83 | VNN1 (0.35) | VNN1HDAC3NCOR2HDAC1HDAC2 | |
| SCHEMBL7358020 | 0.83 | VNN1 (0.35) | VNN1HDAC3NCOR2HDAC1HDAC2 | |
| SCHEMBL7362657 | 0.82 | VNN1 (0.34) | VNN1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL7362655 | 0.82 | VNN1 (0.34) | VNN1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL7363333 | 0.78 | MAPKAPK2 (0.40) | HDAC3NCOR2MAPKAPK2ALDH1A1NPSR1 | |
| SCHEMBL7359969 | 0.77 | VNN1 (0.37) | VNN1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL7359974 | 0.77 | VNN1 (0.37) | VNN1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL4259491 | 0.77 | P2RX7 (0.41) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741708-B1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1998-05-20 | — | — | EP | claimed |
| US-5668157-A | Cyanoguanidines as K-channel blockers | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | claimed |
| EP-0741708-A1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | PHARMACIA & UPJOHN COMPANY (US) | 1996-11-13 | — | — | EP | claimed |
| WO-1995020579-A1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-03 | — | — | WO | claimed |
| EP-0741708-B1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5668157-A | Cyanoguanidines as K-channel blockers | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0741708-A1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | PHARMACIA & UPJOHN COMPANY (US) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020579-A1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-03 | — | — | WO | disclosed |