Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358018 | 0.89 | VNN1 (0.35) | VNN1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL7358020 | 0.89 | VNN1 (0.35) | VNN1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL7363331 | 0.85 | VNN1 (0.35) | VNN1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL7363327 | 0.85 | VNN1 (0.35) | VNN1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL7362657 | 0.84 | VNN1 (0.34) | VNN1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL7362655 | 0.84 | VNN1 (0.34) | VNN1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL7357917 | 0.82 | P2RX7 (0.41) | MAPK1 | |
| SCHEMBL13949283 | 0.82 | P2RX7 (0.41) | MAPK1 | |
| SCHEMBL4259491 | 0.82 | P2RX7 (0.41) | MAPK1 | |
| SCHEMBL8619031 | 0.79 | HDAC3 (0.33) | VNN1HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703904-B1 | PYRIMIDINE CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1999-02-24 | — | — | EP | claimed |
| US-5633374-A | Pyrimidine, cyanoguanidines as K-channel blockers | THE UPJOHN COMPANY (US) | 1997-05-27 | — | — | US | claimed |
| EP-0703904-B1 | PYRIMIDINE CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1999-02-24 | — | — | EP | disclosed |
| US-5633374-A | Pyrimidine, cyanoguanidines as K-channel blockers | THE UPJOHN COMPANY (US) | 1997-05-27 | — | — | US | disclosed |