Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | G6PD | P11413 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16447132 | 0.98 | KDM4E (0.44) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL29073014 | 0.85 | TAAR1 (0.55) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL28288419 | 0.81 | MAPT (0.52) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL5416008 | 0.81 | SLC6A2 (0.45) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL5413155 | 0.81 | L3MBTL1 (0.55) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL14486495 | 0.81 | SLC6A2 (0.45) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL24018796 | 0.80 | ALDH1A1 (0.54) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL3291252 | 0.80 | MAPT (0.46) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL3288376 | 0.80 | MAPT (0.46) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL22389474 | 0.78 | RIPK1 (0.57) | MAPTALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3580220-B1 | AMINOTRIAZOLOPYRIDINES AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-11-17 | — | — | EP | disclosed |
| CN-104395324-B | Mi Zuo Bing oxadiazoles and imidazo thiadiazoles derivative | 阿瑞斯贸易股份有限公司 | 2017-09-12 | — | — | CN | disclosed |
| WO-2016041618-A1 | SUBSTITUTED INDAZOLES AND RELATED HETEROCYCLES | MERCK PATENT GMBH (DE) | 2016-03-24 | — | — | WO | disclosed |
| CN-104395324-A | Imidazo-oxadiazole and imidazo-thiadiazole derivatives | ARES TRADING SA | 2015-03-04 | — | — | CN | disclosed |
| EP-1259506-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6387911-B1 | Pyrazinone thrombin inhibitors | MERCK & CO., INC. | 2002-05-14 | — | — | US | disclosed |
| WO-2001038323-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2001-05-31 | — | — | WO | disclosed |