Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8588884 | 0.92 | MEN1 (0.43) | MEN1KMT2AITGA4ITGB7RAB9A | |
| SCHEMBL30841321 | 0.81 | ITGA4 (0.46) | MEN1KMT2AITGA4ITGB7RAB9A | |
| SCHEMBL8590776 | 0.79 | SLC15A1 (0.45) | MEN1KMT2ARAB9ANPC1LTA4H | |
| SCHEMBL2388059 | 0.77 | CTSL (0.49) | MEN1KMT2AITGA4ITGB7CTSL | |
| SCHEMBL6904576 | 0.77 | ABCB1 (0.47) | ALDH1A1LTA4H | |
| SCHEMBL9330125 | 0.77 | ABCB1 (0.47) | ALDH1A1LTA4H | |
| SCHEMBL7281801 | 0.75 | MEN1 (0.52) | MEN1KMT2AITGA4ITGB7RAB9A | |
| SCHEMBL9706834 | 0.74 | MC4R (0.51) | MEN1KMT2AITGA4ITGB7RAB9A | |
| SCHEMBL1151902 | 0.73 | CTSB (0.46) | MEN1KMT2AALDH1A1LTA4H | |
| SCHEMBL9023544 | 0.73 | SLC15A1 (0.45) | MEN1KMT2ACTSLALDH1A1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998038990-A1 | METHOD OF TREATING TRAUMA ASSOCIATED WITH BRAIN, SPINAL CORD OR PERIPHERAL NERVE INJURY USING CARBOBENZYLOXY N-PROTECTED DI- AND TRIPEPTIDE PHENYLALANINALS | HOECHST MARION ROUSSEL, INC. (US) | 1998-09-11 | — | — | WO | disclosed |
| EP-0802909-A2 | SUBSTITUTED OXAZOLIDINE CALPAIN AND/OR CATHEPSIN B INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1997-10-29 | — | — | EP | disclosed |
| WO-1996021655-A2 | SUBSTITUTED OXAZOLIDINE CALPAIN AND/OR CATHEPSIN B INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1996-07-18 | — | — | WO | disclosed |