Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366065 | 0.87 | MIF (0.39) | CAMKK2NPC1RAB9APDPK1KDM4E | |
| SCHEMBL7363579 | 0.83 | MAPT (0.49) | CREBBPKDM4EALDH1A1TP53CYP1A2 | |
| SCHEMBL7365409 | 0.83 | ALDH1A1 (0.44) | MAPK1NPC1RAB9APDPK1KDM4E | |
| SCHEMBL7364846 | 0.80 | NPC1 (0.43) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL7367312 | 0.76 | ALDH1A1 (0.47) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL15536207 | 0.74 | TYK2 (0.54) | IKBKBTYK2CHUKMKNK1MKNK2 | |
| SCHEMBL7365563 | 0.73 | CDK8 (0.46) | NPC1RAB9APDPK1ALDH1A1PRKDC | |
| SCHEMBL7367836 | 0.71 | IKBKB (0.42) | IKBKBTYK2CHUKMKNK1MKNK2 | |
| SCHEMBL7370381 | 0.71 | NR4A2 (0.37) | CREBBPKDM4EALDH1A1HPGD | |
| SCHEMBL7359478 | 0.70 | MIF (0.42) | IKBKBCHUKKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716954-A | ANTIINFLAMMATORY AGENT, ANTIHISTAMINES, IMMUNOSUPPRESSION,AUTOIMMUNE DISEASES | SYNTEX U.S.A. INC. (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |