Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.45 |
| ▸ | CECR2 | Q9BXF3 | 4/20 | 0.44 |
| ▸ | TAF1 | P21675 | 3/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 4/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366065 | 0.84 | MIF (0.39) | JAK3CYP2D6ALDH1A1KDM4EMEN1 | |
| SCHEMBL7363528 | 0.83 | IKBKB (0.40) | CYP2D6OPRD1KCNH2CREBBPALDH1A1 | |
| SCHEMBL7365409 | 0.82 | ALDH1A1 (0.44) | MAPTOPRD1KCNH2ALDH1A1HPGD | |
| SCHEMBL7364846 | 0.79 | NPC1 (0.43) | MAPTALDH1A1HPGDKDM4ECYP3A4 | |
| SCHEMBL7367312 | 0.76 | ALDH1A1 (0.47) | MAPTALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL7365557 | 0.73 | MAPT (0.48) | MAPTATRCECR2TAF1NCOA1 | |
| SCHEMBL7365563 | 0.72 | CDK8 (0.46) | MAPTPDK2ALDH1A1KMT2AERN1 | |
| SCHEMBL7370381 | 0.71 | NR4A2 (0.37) | CREBBPALDH1A1HPGDKDM4E | |
| SCHEMBL7361674 | 0.68 | MAOB (0.42) | MAPTNCOA1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7359478 | 0.68 | MIF (0.42) | MAPTBRD4ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716954-A | ANTIINFLAMMATORY AGENT, ANTIHISTAMINES, IMMUNOSUPPRESSION,AUTOIMMUNE DISEASES | SYNTEX U.S.A. INC. (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |