Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.40 |
| ▸ | PPARA | Q07869 | 9/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 2/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7661859 | 0.82 | PPARG (0.35) | PPARGPPARACES1 | |
| SCHEMBL6801355 | 0.81 | CTSL (0.38) | PPARGPPARAFAAHCES1POLB | |
| SCHEMBL6797431 | 0.73 | TP53 (0.35) | PPARGPPARA | |
| SCHEMBL7364307 | 0.72 | PPARG (0.33) | PPARGPPARAFAAHCES1 | |
| SCHEMBL6807131 | 0.70 | PPARG (0.38) | PPARGPPARAFAAHCES1POLB | |
| SCHEMBL6807134 | 0.67 | CTSL (0.44) | PPARGPPARAFAAHCES1POLB | |
| SCHEMBL6800322 | 0.65 | KDM4E (0.38) | PPARGPPARAFAAHPOLBIKBKB | |
| SCHEMBL7363588 | 0.65 | ALDH1A1 (0.37) | PPARGPPARAPOLBIKBKB | |
| SCHEMBL7430870 | 0.64 | PPARG (0.32) | PPARGPPARAFAAHCES1 | |
| SCHEMBL6799382 | 0.64 | TP53 (0.37) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1159273-A1 | COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CATHEPSIN S | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000051998-A1 | COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CATHEPSIN S | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-09-08 | — | — | WO | disclosed |