Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | PDE4A | P27815 | 3/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CDC25C | P30307 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9276135 | 0.84 | HDAC1 (0.51) | PDE4BPDE4APDE4CPDE4DHDAC1 | |
| SCHEMBL9276295 | 0.80 | PDE4B (0.51) | KMT2AMEN1PDE4BPDE4APDE4C | |
| SCHEMBL9272695 | 0.80 | PDE4B (0.50) | KMT2AMEN1ALDH1A1PDE4BPDE4A | |
| SCHEMBL7397257 | 0.79 | KMT2A (0.56) | KCNH2KMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL9272449 | 0.79 | ALDH1A1 (0.57) | KCNH2KMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL16056331 | 0.78 | KMT2A (0.53) | KCNH2KMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL7367293 | 0.77 | EPHX2 (0.55) | KMT2ASMN1; SMN2MAPTMEN1PDE5A | |
| SCHEMBL7361261 | 0.75 | PDE4B (0.42) | KMT2AMEN1PDE4BPDE4APDE4C | |
| SCHEMBL1157335 | 0.75 | CYP19A1 (0.61) | KMT2ASMN1; SMN2MAPTMEN1PDE5A | |
| SCHEMBL9275374 | 0.74 | KDM4E (0.53) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538384-A4 | OXAMIDES | SMITHKLINE BEECHAM CORP (US) | 1995-04-12 | — | — | EP | disclosed |
| EP-0538384-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1992000968-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |