Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369403 | 0.92 | KDM4E (0.44) | KDM4EPOLBTSHRHSD17B10KAT2B | |
| SCHEMBL7367931 | 0.84 | HPGD (0.55) | KDM4EPOLBTSHRHSD17B10KAT2B | |
| SCHEMBL7363886 | 0.84 | KDM4E (0.44) | KDM4EPOLBTSHRSMN1; SMN2HPGD | |
| SCHEMBL7364392 | 0.84 | KDM4E (0.51) | KDM4EPOLBTSHRHSD17B10KAT2B | |
| SCHEMBL7363039 | 0.83 | PDE4A (0.47) | KDM4EPOLBHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL7369736 | 0.82 | TSHR (0.45) | KDM4EPOLBTSHRSMN1; SMN2HPGD | |
| SCHEMBL7359750 | 0.81 | PDE4A (0.50) | KDM4ETSHRALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL7366365 | 0.80 | PDE4A (0.52) | KDM4EPOLBTSHRALDH1A1USP2 | |
| SCHEMBL7369500 | 0.78 | MAPK1 (0.48) | KDM4EPOLBTSHRSMN1; SMN2HPGD | |
| SCHEMBL7370597 | 0.78 | L3MBTL1 (0.50) | KAT2BSMN1; SMN2ALDH1A1L3MBTL1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |