Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363317 | 0.91 | HPGD (0.57) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7363279 | 0.89 | GRM5 (0.48) | ALDH1A1HPGDMEN1KMT2AKAT2B | |
| SCHEMBL7367332 | 0.88 | HTT (0.53) | ALDH1A1HPGDMEN1KMT2AKAT2B | |
| SCHEMBL7366676 | 0.86 | NCOA1 (0.48) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7361460 | 0.85 | NPSR1 (0.49) | ALDH1A1HPGDPDE4APDE4BPDE4C | |
| SCHEMBL7363855 | 0.85 | PDE4A (0.47) | ALDH1A1HPGDMEN1KMT2AMAPK1 | |
| SCHEMBL7361949 | 0.84 | PDE4A (0.53) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9168570 | 0.83 | NPSR1 (0.56) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7366959 | 0.83 | L3MBTL1 (0.58) | ALDH1A1HPGDPDE4APDE4BPDE4C | |
| SCHEMBL7367052 | 0.82 | F2RL3 (0.53) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |