Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361460 | 0.91 | NPSR1 (0.49) | HTTNPSR1GAAHPGDADORA3 | |
| SCHEMBL7364737 | 0.90 | HPGD (0.53) | HTTNPSR1GAAHPGDPLA2G10 | |
| SCHEMBL7366676 | 0.89 | NCOA1 (0.48) | HTTNPSR1GAAHPGDADORA3 | |
| SCHEMBL9168570 | 0.88 | NPSR1 (0.56) | HTTNPSR1GAAADORA3ALDH1A1 | |
| SCHEMBL7363944 | 0.88 | ALDH1A1 (0.54) | HTTNPSR1GAAHPGDADORA3 | |
| SCHEMBL7366959 | 0.85 | L3MBTL1 (0.58) | NPSR1GAAHPGDALDH1A1ALOX5 | |
| SCHEMBL7361949 | 0.82 | PDE4A (0.53) | HTTNPSR1GAAHPGDADORA3 | |
| SCHEMBL7367676 | 0.81 | NPSR1 (0.49) | HTTNPSR1GAAHPGDADORA3 | |
| SCHEMBL7361626 | 0.80 | ALDH1A1 (0.56) | HTTNPSR1HPGDRORCALDH1A1 | |
| SCHEMBL9165637 | 0.80 | NPSR1 (0.56) | HTTNPSR1GAAHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |