SCHEMBL7366959

SCHEMBL7366959

Cc1ccc(-c2nn(-c3ccccc3)c(=O)c3cccnc23)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.58
GAA P10253 2/20 0.53
NPSR1 Q6W5P4 2/20 0.53
ALDH1A1 P00352 4/20 0.50
KDM4E B2RXH2 1/20 0.50
LMNA P02545 1/20 0.50
HPGD P15428 1/20 0.50
CCNA2 P20248 1/20 0.48
CDK2 P24941 1/20 0.48
ALOX5 P09917 1/20 0.47
PDE4A P27815 1/20 0.47
PDE4B Q07343 1/20 0.47
PDE4C Q08493 1/20 0.47
PDE4D Q08499 1/20 0.47
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
AURKA O14965 1/20 0.45
RAB9A P51151 1/20 0.44
ENPP1 P22413 1/20 0.44
MDM2 Q00987 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9168570 0.91 NPSR1 (0.56) L3MBTL1GAANPSR1ALDH1A1KDM4E
SCHEMBL7363896 0.90 L3MBTL1 (0.58) L3MBTL1GAANPSR1ALDH1A1KDM4E
SCHEMBL7361949 0.86 PDE4A (0.53) L3MBTL1GAANPSR1ALDH1A1KDM4E
SCHEMBL7367332 0.85 HTT (0.53) L3MBTL1GAANPSR1ALDH1A1LMNA
SCHEMBL7366676 0.83 NCOA1 (0.48) L3MBTL1GAANPSR1ALDH1A1KDM4E
SCHEMBL7361460 0.83 NPSR1 (0.49) L3MBTL1GAANPSR1ALDH1A1LMNA
SCHEMBL7363944 0.83 ALDH1A1 (0.54) GAANPSR1ALDH1A1KDM4EHPGD
SCHEMBL9165637 0.82 NPSR1 (0.56) L3MBTL1GAANPSR1ALDH1A1KDM4E
SCHEMBL16535885 0.80 ALDH1A1 (0.48) L3MBTL1GAANPSR1ALDH1A1LMNA
SCHEMBL7364352 0.80 KMT2A (0.48) L3MBTL1GAANPSR1ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0612321-A1 PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY SYNTEX (U.S.A.) INC. (US) 1994-08-31 EP disclosed
WO-1993007146-A1 BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY SYNTEX (U.S.A.) INC. (US) 1993-04-15 WO disclosed