Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NT5E | P21589 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TIMP3 | P35625 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364052 | 0.98 | LMNA (0.45) | LMNATSHRALDH1A1NT5ESMN1; SMN2 | |
| Sulfuric Acid SCHEMBL1882493 | 0.80 | CA9 (0.52) | LMNATSHRALDH1A1NT5ESMN1; SMN2 | |
| SCHEMBL11021824 | 0.80 | TSHR (0.46) | TSHRALDH1A1SMN1; SMN2TDP1KMT2A | |
| SCHEMBL11567649 | 0.79 | ENPP2 (0.45) | LMNACA2CA9CA1GAA | |
| Nitroanilide SCHEMBL6868720 | 0.79 | CA2 (0.44) | LMNATSHRALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL27460156 | 0.79 | CA2 (0.57) | TSHRTDP1KMT2AMEN1CA2 | |
| Nitroanilide SCHEMBL28474437 | 0.78 | CA2 (0.43) | LMNAALDH1A1SMN1; SMN2TDP1KMT2A | |
| Nitric Acid SCHEMBL20984254 | 0.76 | CA1 (0.53) | LMNATSHRALDH1A1NT5ESMN1; SMN2 | |
| SCHEMBL30336 | 0.76 | MAPT (0.47) | LMNATSHRALDH1A1TDP1KMT2A | |
| SCHEMBL9154737 | 0.75 | SNCA (0.60) | LMNATSHRALDH1A1NT5ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086076-A1 | SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE | Vertex Pharmaceuticals Incorporated (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999065870-A2 | SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1999-12-23 | — | — | WO | disclosed |