Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9405352 | 0.85 | SIGMAR1 (0.52) | SIGMAR1 | |
| SCHEMBL3667235 | 0.85 | PARP15 (0.55) | — | |
| SCHEMBL7362469 | 0.84 | SIGMAR1 (0.71) | SIGMAR1 | |
| SCHEMBL7362689 | 0.83 | SIGMAR1 (1.00) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7356651 | 0.83 | SIGMAR1 (0.69) | SIGMAR1 | |
| SCHEMBL2056311 | 0.81 | SIGMAR1 (0.50) | SIGMAR1 | |
| SCHEMBL9340244 | 0.81 | SIGMAR1 (0.66) | SIGMAR1 | |
| SCHEMBL7296120 | 0.81 | ALDH1A1 (0.65) | — | |
| SCHEMBL7362580 | 0.80 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL7294940 | 0.79 | SIGMAR1 (0.70) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5266572-A | Antipsychotic 1-cycloalkylpiperidines | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-11-30 | — | — | US | claimed |
| US-5231099-A | USE OF SIGMA RECEPTOR ANTAGONISTS TO ENHANCE THE EFFECTS OF ANTIPSYCHOTIC DRUGS | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-07-27 | — | — | US | claimed |
| EP-0490962-A4 | ANTIPSYCHOTIC 1-CYCLOALKYLPIPERIDINES | — | 1993-03-03 | — | — | EP | claimed |
| US-5180729-A | Phthalimidoalkylpiperidine as narcotic antagonist | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-01-19 | — | — | US | claimed |
| US-5162341-A | Piperidine Derivatives | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-11-10 | — | — | US | claimed |
| WO-1992014464-A1 | USE OF SIGMA RECEPTOR ANTAGONISTS FOR TREATMENT OF COCAINE ABUSE | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-09-03 | — | — | WO | claimed |
| WO-1992014463-A1 | USE OF SIGMA RECEPTOR ANTAGONISTS FOR TREATMENT OF AMPHETAMINE ABUSE | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-09-03 | — | — | WO | claimed |
| EP-0490962-A1 | ANTIPSYCHOTIC 1-CYCLOALKYLPIPERIDINES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-06-24 | — | — | EP | claimed |
| WO-1991003243-A1 | ANTIPSYCHOTIC 1-CYCLOALKYLPIPERIDINES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-03-21 | — | — | WO | claimed |
| US-5296479-A | Treating physiological or drug-induced psychosis or dyskinesia | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-03-22 | — | — | US | disclosed |
| EP-0580776-A1 | USE OF SIGMA RECEPTOR ANTAGONISTS TO ENHANCE THE EFFECTS OF ANTIPSYCHOTIC DRUGS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-02-02 | — | — | EP | disclosed |
| US-5266572-A | Antipsychotic 1-cycloalkylpiperidines | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-11-30 | — | — | US | disclosed |
| US-5243048-A | Treatment of drug-induced or physiological psychosis or dyskinesia; side effect reduction | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-09-07 | — | — | US | disclosed |
| US-5231099-A | USE OF SIGMA RECEPTOR ANTAGONISTS TO ENHANCE THE EFFECTS OF ANTIPSYCHOTIC DRUGS | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-07-27 | — | — | US | disclosed |
| WO-1992018127-A1 | USE OF SIGMA RECEPTOR ANTAGONISTS TO ENHANCE THE EFFECTS OF ANTIPSYCHOTIC DRUGS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-10-29 | — | — | WO | disclosed |
| WO-1992014464-A1 | USE OF SIGMA RECEPTOR ANTAGONISTS FOR TREATMENT OF COCAINE ABUSE | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-09-03 | — | — | WO | disclosed |
| WO-1992014463-A1 | USE OF SIGMA RECEPTOR ANTAGONISTS FOR TREATMENT OF AMPHETAMINE ABUSE | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-09-03 | — | — | WO | disclosed |
| EP-0490962-A1 | ANTIPSYCHOTIC 1-CYCLOALKYLPIPERIDINES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-06-24 | — | — | EP | disclosed |
| US-5109002-A | ANTIPSYCHOTIC 1-CYCLOALKYLPIPERIDINES | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-04-28 | — | — | US | disclosed |
| WO-1991003243-A1 | ANTIPSYCHOTIC 1-CYCLOALKYLPIPERIDINES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-03-21 | — | — | WO | disclosed |