Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NEK1 | Q96PY6 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371143 | 0.92 | KDM4E (0.53) | KDM4ETSHRPOLBHSD17B10KDM5B | |
| SCHEMBL7367931 | 0.88 | HPGD (0.55) | KDM4ETSHRPOLBHSD17B10KDM5B | |
| SCHEMBL7369732 | 0.84 | KDM4E (0.44) | KDM4ETSHRPOLBHSD17B10KAT2B | |
| SCHEMBL8699836 | 0.83 | TBXAS1 (0.45) | KDM4ETSHRKDM5BKAT2BALDH1A1 | |
| SCHEMBL7366042 | 0.83 | PIK3CD (0.50) | KDM5BKAT2BPIK3CDABL1EGFR | |
| SCHEMBL7370126 | 0.82 | GRM5 (0.48) | KDM5BALDH1A1HPGDL3MBTL1GRM5 | |
| SCHEMBL7364396 | 0.82 | ALDH1A1 (0.52) | TSHRPOLBKDM5BKAT2BALDH1A1 | |
| SCHEMBL7370208 | 0.80 | PDE4A (0.53) | HSD17B10KDM5BHPGDHTT | |
| SCHEMBL7365433 | 0.80 | ADORA1 (0.39) | ALDH1A1L3MBTL1TGFBR1PIK3CDABL1 | |
| SCHEMBL7359391 | 0.80 | MAPK10 (0.50) | KDM4ETSHRALDH1A1HPGDGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |