Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | PMM2 | O15305 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8699836 | 0.92 | TBXAS1 (0.45) | ALDH1A1TSHRNPSR1LMNAHPGD | |
| SCHEMBL7367933 | 0.89 | ALDH1A1 (0.56) | ALDH1A1TSHRNPSR1LMNAHPGD | |
| SCHEMBL7359391 | 0.86 | MAPK10 (0.50) | ALDH1A1TSHRNPSR1LMNAHPGD | |
| SCHEMBL7372566 | 0.85 | PDE4A (0.58) | ALDH1A1TSHRHPGDL3MBTL1KDM5B | |
| SCHEMBL7369736 | 0.84 | TSHR (0.45) | ALDH1A1TSHRNPSR1LMNAHPGD | |
| SCHEMBL7362649 | 0.84 | PDE4A (0.50) | ALDH1A1TSHRNPSR1LMNAHPGD | |
| SCHEMBL7366044 | 0.83 | TP53 (0.45) | ALDH1A1LMNAHPGDKAT2BKMT2A | |
| SCHEMBL7364392 | 0.82 | KDM4E (0.51) | ALDH1A1TSHRNPSR1HPGDTGFBR1 | |
| SCHEMBL7365437 | 0.81 | PDE4A (0.43) | ALDH1A1TGFBR1RAB9AMEN1KMT2A | |
| SCHEMBL7370212 | 0.81 | PDE4A (0.59) | ALDH1A1NPSR1L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |