Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | DRD4 | P21917 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | SLC6A12 | P48065 | 4/20 | 0.59 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.57 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.57 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.57 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.57 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.57 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177672 | 0.80 | HTR4 (0.54) | POLBDRD4CYP3A4CYP2D6DRD2 | |
| SCHEMBL21900251 | 0.78 | POLB (0.74) | SIGMAR1POLBDRD4MEN1KMT2A | |
| SCHEMBL3959130 | 0.78 | SIGMAR1 (0.73) | SIGMAR1POLBDRD4MEN1KMT2A | |
| SCHEMBL7217989 | 0.78 | SIGMAR1 (1.00) | SIGMAR1POLBDRD4MEN1KMT2A | |
| SCHEMBL6956820 | 0.78 | SIGMAR1 (0.73) | SIGMAR1POLBDRD4MEN1KMT2A | |
| SCHEMBL16828026 | 0.78 | KMT2A (0.79) | SIGMAR1POLBDRD4MEN1KMT2A | |
| SCHEMBL10107494 | 0.77 | SLC6A12 (0.66) | SIGMAR1POLBDRD4MEN1KMT2A | |
| SCHEMBL7239441 | 0.77 | CCR3 (0.72) | SIGMAR1POLBDRD4MEN1KMT2A | |
| SCHEMBL14214884 | 0.77 | MEN1 (0.72) | SIGMAR1POLBDRD4MEN1KMT2A | |
| SCHEMBL9651278 | 0.76 | POLB (0.61) | SIGMAR1POLBDRD4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5604239-A | GASTROINTESTINAL AND PSYCHOLOGICAL DISORDERS | G. D. SEARLE & CO. (US) | 1997-02-18 | — | — | US | disclosed |
| US-5591749-A | ANXIOLYTIC AND ANTIDEPRESSANT AGENTS; GASTROINTESTINAL AND PSYCHOLOGICAL DISORDERS | G. D. SEARLE & CO. (US) | 1997-01-07 | — | — | US | disclosed |
| US-5434161-A | FOR TREATING ANXIETY, PSYCHOSES, DEPRESSION OR GASTROINTESTINAL MOTILITY | G. D. SEARLE & CO. (US) | 1995-07-18 | — | — | US | disclosed |
| EP-0530353-A1 | NEW IMIDAZOPYRIDINES AS SEROTONERGIC 5-HT 3? ANTAGONISTS | G.D. SEARLE & CO. (US) | 1993-03-10 | — | — | EP | disclosed |
| EP-0504679-A1 | New imidazopyridines as serotonergic 5-HT3 antagonists | G.D. Searle & Co. (US) | 1992-09-23 | — | — | EP | disclosed |
| WO-1992015593-A1 | NEW IMIDAZOPYRIDINES AS SEROTONERGIC 5-HT3 ANTAGONISTS | G.D. SEARLE & CO. (US) | 1992-09-17 | — | — | WO | disclosed |