Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RORC | P51449 | 3/20 | 0.47 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.42 |
| ▸ | RARG | P13631 | 1/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367676 | 0.91 | NPSR1 (0.49) | HPGDNPSR1GAAHTTALOX5 | |
| SCHEMBL7367332 | 0.90 | HTT (0.53) | HPGDNPSR1GAAHTTRORC | |
| SCHEMBL7367503 | 0.89 | HPGD (0.48) | HPGDNPSR1GAAHTTMEN1 | |
| SCHEMBL7363317 | 0.88 | HPGD (0.57) | HPGDNPSR1GAAMEN1KMT2A | |
| SCHEMBL7363896 | 0.85 | L3MBTL1 (0.58) | HPGDNPSR1GAAHTTALOX5 | |
| SCHEMBL7365986 | 0.82 | PDE4A (0.53) | HPGDNPSR1GAAHTTMEN1 | |
| SCHEMBL7361460 | 0.81 | NPSR1 (0.49) | HPGDNPSR1GAAHTTALOX5 | |
| SCHEMBL7365466 | 0.80 | ALDH1A1 (0.56) | HPGDNPSR1HTTRORCMEN1 | |
| SCHEMBL7370613 | 0.80 | HPGD (0.52) | HPGDGAARORCPDE4APDE4B | |
| SCHEMBL7360998 | 0.80 | HPGD (0.52) | HPGDHTTRORCMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |