Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.49 |
| ▸ | RORC | P51449 | 2/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360999 | 0.91 | HPGD (0.53) | HPGDRORCPDE4ARAB9ATSHR | |
| SCHEMBL7365898 | 0.91 | PDE4B (0.49) | HPGDPDE4BRORCTBXAS1PDE4A | |
| SCHEMBL7361314 | 0.89 | TBXAS1 (0.46) | HPGDPDE4BTBXAS1PDE4ARAB9A | |
| SCHEMBL7365662 | 0.87 | HPGD (0.55) | HPGDPDE4BTBXAS1PDE4ATSHR | |
| SCHEMBL7367402 | 0.87 | NCOA1 (0.46) | HPGDTBXAS1RAB9ATSHRGAA | |
| SCHEMBL7365466 | 0.86 | ALDH1A1 (0.56) | HPGDPDE4BRORCPDE4AALOX15 | |
| SCHEMBL7372162 | 0.85 | RAB9A (0.51) | PDE4BTBXAS1PDE4ARAB9APDE4C | |
| SCHEMBL7368362 | 0.84 | PDE4A (0.54) | HPGDPDE4BRORCPDE4AALOX15 | |
| SCHEMBL7365028 | 0.82 | KDM4E (0.50) | HPGDPDE4BTBXAS1PDE4ATSHR | |
| SCHEMBL7369488 | 0.81 | HPGD (0.50) | HPGDPDE4BPDE4ARAB9AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |