Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 20/20 | 0.52 |
| ▸ | CTRC | Q99895 | 2/20 | 0.52 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | KLK1 | P06870 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7365316 | 1.00 | F2 (0.52) | F2CTRCF10KLK1 | |
| SCHEMBL7360493 | 0.99 | F2 (0.53) | F2CTRCF10KLK1 | |
| SCHEMBL7359256 | 0.99 | F2 (0.53) | F2CTRCF10KLK1 | |
| SCHEMBL7443425 | 0.91 | F2 (0.54) | F2CTRCF10KLK1 | |
| SCHEMBL7422682 | 0.90 | F2 (0.53) | F2CTRCF10KLK1 | |
| SCHEMBL7479296 | 0.90 | F2 (0.48) | F2CTRCF10KLK1 | |
| SCHEMBL7423601 | 0.88 | F2 (0.53) | F2CTRCF10KLK1 | |
| SCHEMBL7418302 | 0.88 | F2 (0.53) | F2CTRCF10KLK1 | |
| SCHEMBL7418322 | 0.86 | MAPT (0.44) | F2CTRCF10KLK1 | |
| Bromide SCHEMBL7425687 | 0.84 | DRD2 (0.46) | F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815103-A1 | TRYPSIN AND THROMBIN INHIBITORS | Novartis AG (CH) | 1998-01-07 | — | — | EP | disclosed |
| WO-1997046553-A1 | THROMBIN INHIBITORS | NOVARTIS AG (CH) | 1997-12-11 | — | — | WO | disclosed |
| WO-1996029327-A1 | TRYPSIN AND THROMBIN INHIBITORS | NOVARTIS AG (CH) | 1996-09-26 | — | — | WO | disclosed |