Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7164256 | 0.89 | TSHR (0.46) | THRBHSD17B10TSHRMAPTALDH1A1 | |
| SCHEMBL7441206 | 0.86 | ALDH1A1 (0.42) | THRBHSD17B10TSHRALDH1A1KMT2A | |
| SCHEMBL7369546 | 0.86 | THRB (0.39) | THRBHSD17B10TSHRMAPTALDH1A1 | |
| SCHEMBL7472452 | 0.86 | THRB (0.39) | THRBHSD17B10TSHRMAPTALDH1A1 | |
| SCHEMBL7369540 | 0.85 | MAPT (0.41) | THRBHSD17B10TSHRMAPTKMT2A | |
| SCHEMBL7368383 | 0.83 | GAA (0.37) | THRBHSD17B10TSHRMAPTKMT2A | |
| SCHEMBL7478535 | 0.83 | THRB (0.40) | THRBHSD17B10TSHRMAPTALDH1A1 | |
| SCHEMBL7365336 | 0.83 | TSHR (0.43) | THRBHSD17B10TSHRMAPTALDH1A1 | |
| SCHEMBL7468966 | 0.83 | BDKRB1 (0.39) | THRBHSD17B10TSHRMAPTKMT2A | |
| SCHEMBL4681020 | 0.82 | TSHR (0.38) | THRBHSD17B10TSHRMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964856-B1 | BICYCLIC AMINO ACIDS | MERCK PATENT GMBH (DE) | 2002-10-09 | — | — | EP | disclosed |
| EP-0964856-A1 | BICYCLIC AMINO ACIDS | MERCK PATENT GmbH (DE) | 1999-12-22 | — | — | EP | disclosed |
| WO-1998035949-A1 | BICYCLIC AMINO ACIDS | MERCK PATENT GMBH (DE) | 1998-08-20 | — | — | WO | disclosed |