Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.39 |
| ▸ | PDE5A | O76074 | 14/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE6D | O43924 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365111 | 0.89 | PDE5A (0.46) | PDE5ANPC1POLBPTK2BALDH1A1 | |
| SCHEMBL9701443 | 0.78 | ALDH1A1 (0.44) | FFAR4PDE5AALDH1A1KDM4EKMT2A | |
| SCHEMBL7365410 | 0.75 | MAPT (0.42) | ALDH1A1KDM4EKMT2AMEN1LMNA | |
| SCHEMBL7369809 | 0.73 | NPC1 (0.36) | FFAR4NPC1POLBPTK2BALDH1A1 | |
| SCHEMBL10040047 | 0.69 | POLB (0.74) | NPC1POLBPTK2BALDH1A1RAB9A | |
| SCHEMBL9370220 | 0.69 | PDE5A (0.47) | PDE5AALDH1A1KDM4EKMT2APDE4A | |
| SCHEMBL7368255 | 0.68 | KDM4E (0.51) | PDE5AALDH1A1KDM4EKMT2APDE4A | |
| SCHEMBL9534290 | 0.68 | KDM4E (0.45) | POLBPTK2BKDM4EPDE10A | |
| SCHEMBL149188 | 0.68 | KMT2A (0.48) | PDE5AALDH1A1KDM4EKMT2APDE4A | |
| SCHEMBL9376126 | 0.68 | PDE5A (0.45) | PDE5AALDH1A1KDM4EKMT2APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613467-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1994-09-07 | — | — | EP | claimed |
| WO-1993010093-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1993-05-27 | — | — | WO | claimed |
| EP-0613467-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1994-09-07 | — | — | EP | disclosed |
| WO-1993010093-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1993-05-27 | — | — | WO | disclosed |