Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 9/20 | 0.55 |
| ▸ | MMP2 | P08253 | 8/20 | 0.55 |
| ▸ | MMP12 | P39900 | 8/20 | 0.55 |
| ▸ | MMP9 | P14780 | 8/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442587 | 0.84 | MMP2 (0.55) | MMP1MMP2MMP12MMP9SMN1; SMN2 | |
| SCHEMBL7369379 | 0.74 | KMT2A (0.67) | MMP1MMP2MMP12MMP9SLC6A2 | |
| SCHEMBL6256905 | 0.74 | AKR1B1 (0.48) | MMP1MMP2MMP12MMP9SMN1; SMN2 | |
| SCHEMBL6735485 | 0.73 | LGMN (0.48) | MMP1MMP2MMP12MMP9SMN1; SMN2 | |
| SCHEMBL7121166 | 0.73 | MAT2A (0.51) | MMP1MMP2MMP12MMP9SMN1; SMN2 | |
| SCHEMBL6237834 | 0.72 | HSD17B10 (0.45) | MMP1MMP2MMP12MMP9SLC6A2 | |
| SCHEMBL3964905 | 0.71 | IDO1 (0.61) | MMP1MMP2MMP12MMP9TP53 | |
| SCHEMBL30741601 | 0.71 | IDO1 (0.61) | MMP1MMP2MMP12MMP9TP53 | |
| SCHEMBL7651783 | 0.71 | RAB9A (0.46) | MMP1MMP2MMP12MMP9SMN1; SMN2 | |
| SCHEMBL27391742 | 0.71 | MMP2 (0.63) | MMP1MMP2MMP12MMP9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4665056-A | CENTRAL NERVOUS SYSTEM DISORDERS | TANABE SEIYAKU CO., LTD. (JP) | 1987-05-12 | — | — | US | disclosed |
| EP-0168042-A2 | Dihydroorotic acid derivatives, processes for their preparing and pharmaceutical composition containing them | TANABE SEIYAKU CO., LTD. (JP) | 1986-01-15 | — | — | EP | disclosed |