Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365163 | 0.86 | EDNRA (0.41) | L3MBTL1ALDH1A1MAPT | |
| SCHEMBL7369632 | 0.78 | PTGS2 (0.48) | L3MBTL1ALDH1A1SMN1; SMN2NPC1LMNA | |
| SCHEMBL7367374 | 0.76 | HPGD (0.48) | SMN1; SMN2LMNA | |
| SCHEMBL7402420 | 0.74 | NUDT1 (0.50) | L3MBTL1ALDH1A1SMN1; SMN2NPC1LMNA | |
| SCHEMBL7372299 | 0.74 | AR (0.43) | — | |
| SCHEMBL1313733 | 0.73 | L3MBTL1 (0.74) | L3MBTL1ALDH1A1SMN1; SMN2NPC1LMNA | |
| SCHEMBL20831533 | 0.73 | TDP1 (0.72) | L3MBTL1ALDH1A1LMNAHTTPOLB | |
| SCHEMBL5669102 | 0.73 | TSHR (0.54) | L3MBTL1ALDH1A1HTTMAPTKMT2A | |
| SCHEMBL3454518 | 0.72 | POLB (0.61) | L3MBTL1ALDH1A1NPC1LMNAPOLB | |
| SCHEMBL311599 | 0.72 | L3MBTL1 (0.59) | L3MBTL1ALDH1A1SMN1; SMN2NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |