SCHEMBL7366452

SCHEMBL7366452

CCP(=O)(NC(C)C(=O)NO)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 9/20 0.52
MMP3 P08254 9/20 0.52
MMP7 P09237 2/20 0.47
MMP9 P14780 2/20 0.47
MMP8 P22894 2/20 0.43
MMP2 P08253 1/20 0.43
TSHR P16473 1/20 0.42
HDAC3 O15379 3/20 0.39
HDAC4 P56524 3/20 0.39
HDAC1 Q13547 3/20 0.39
HDAC7 Q8WUI4 3/20 0.39
HDAC2 Q92769 3/20 0.39
HDAC10 Q969S8 3/20 0.39
HDAC11 Q96DB2 3/20 0.39
HDAC8 Q9BY41 3/20 0.39
HDAC6 Q9UBN7 3/20 0.39
HDAC9 Q9UKV0 3/20 0.39
HDAC5 Q9UQL6 3/20 0.39
MEP1B Q16820 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7366454 1.00 MMP1 (0.52) MMP1MMP3MMP7MMP9MMP8
SCHEMBL7366457 1.00 MMP1 (0.52) MMP1MMP3MMP7MMP9MMP8
SCHEMBL7406308 1.00 MMP1 (0.52) MMP1MMP3MMP7MMP9MMP8
SCHEMBL7553125 0.80 MMP1 (0.68) MMP1MMP3MMP7MMP9MMP8
SCHEMBL18801541 0.71 BTN3A1 (0.49) MMP8TSHR
SCHEMBL7407555 0.69 MMP1 (1.00) MMP1MMP3MMP7MMP9MMP8
SCHEMBL7403305 0.69 MMP1 (1.00) MMP1MMP3MMP7MMP9MMP8
SCHEMBL7403306 0.69 MMP1 (1.00) MMP1MMP3MMP7MMP9MMP8
SCHEMBL7405291 0.69 MMP1 (1.00) MMP1MMP3MMP7MMP9MMP8
SCHEMBL7413732 0.67 SMN1; SMN2 (0.59) HDAC3HDAC1HDAC7HDAC2HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0925303-B1 PHOSPHINIC ACID AMIDES AS MATRIX METALLOPROTEASE INHIBITORS PROCTER & GAMBLE (US) 2002-10-23 EP claimed
EP-0925303-A1 PHOSPHINIC ACID AMIDES AS MATRIX METALLOPROTEASE INHIBITORS THE PROCTER & GAMBLE COMPANY (US) 1999-06-30 EP claimed
WO-1998008853-A9 PHOSPHINIC ACID AMIDES AS MATRIX METALLOPROTEASE INHIBITORS 1998-08-06 WO claimed
WO-1998008853-A1 PHOSPHINIC ACID AMIDES AS MATRIX METALLOPROTEASE INHIBITORS THE PROCTER & GAMBLE COMPANY (US) 1998-03-05 WO claimed
EP-0925303-B1 PHOSPHINIC ACID AMIDES AS MATRIX METALLOPROTEASE INHIBITORS PROCTER & GAMBLE (US) 2002-10-23 EP disclosed
EP-0925303-A1 PHOSPHINIC ACID AMIDES AS MATRIX METALLOPROTEASE INHIBITORS THE PROCTER & GAMBLE COMPANY (US) 1999-06-30 EP disclosed
WO-1998008853-A9 PHOSPHINIC ACID AMIDES AS MATRIX METALLOPROTEASE INHIBITORS 1998-08-06 WO disclosed
WO-1998008853-A1 PHOSPHINIC ACID AMIDES AS MATRIX METALLOPROTEASE INHIBITORS THE PROCTER & GAMBLE COMPANY (US) 1998-03-05 WO disclosed