Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365535 | 0.87 | EPHX2 (0.51) | RIPK1DDR1 | |
| SCHEMBL8253718 | 0.81 | DDR1 (0.50) | DDR1 | |
| SCHEMBL5006708 | 0.79 | RIPK1 (0.41) | RIPK1 | |
| SCHEMBL7366760 | 0.78 | DDR1 (0.40) | RIPK1DDR1 | |
| SCHEMBL14035784 | 0.78 | L3MBTL1 (0.47) | DDR1 | |
| SCHEMBL5003176 | 0.77 | RIPK1 (0.39) | RIPK1DDR1 | |
| SCHEMBL8061739 | 0.74 | TSHR (0.52) | RIPK1 | |
| SCHEMBL2778215 | 0.74 | RIPK1 (0.46) | RIPK1 | |
| SCHEMBL7367349 | 0.73 | RIPK1 (0.47) | RIPK1DDR1 | |
| SCHEMBL16529584 | 0.73 | DDR1 (0.60) | DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259506-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6387911-B1 | Pyrazinone thrombin inhibitors | MERCK & CO., INC. | 2002-05-14 | — | — | US | disclosed |
| WO-2001038323-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2001-05-31 | — | — | WO | disclosed |