Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.47 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367629 | 0.85 | LMNA (0.50) | RIPK1DDR1HPGDALDH1A1HSD17B10 | |
| SCHEMBL7367345 | 0.78 | DDR1 (0.40) | RIPK1DDR1HPGDALDH1A1ALOX15 | |
| SCHEMBL2543341 | 0.77 | MTNR1A (0.40) | RIPK1HPGDLMNACDK5TAOK1 | |
| SCHEMBL7366674 | 0.77 | RIPK1 (0.45) | RIPK1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL2778215 | 0.74 | RIPK1 (0.46) | RIPK1HPGDALDH1A1LMNACDK5 | |
| SCHEMBL8061739 | 0.74 | TSHR (0.52) | RIPK1HSD17B10CDK5TAOK1CLK4 | |
| SCHEMBL7367009 | 0.73 | KMT2A (0.45) | RIPK1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL7366762 | 0.73 | RIPK1 (0.50) | RIPK1DDR1 | |
| SCHEMBL16529983 | 0.73 | DDR1 (0.53) | DDR1HPGDALDH1A1ALOX15HSD17B10 | |
| SCHEMBL394807 | 0.73 | RIPK1 (0.65) | RIPK1ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259506-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6387911-B1 | Pyrazinone thrombin inhibitors | MERCK & CO., INC. | 2002-05-14 | — | — | US | disclosed |
| WO-2001038323-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2001-05-31 | — | — | WO | disclosed |