Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 17/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365533 | 0.87 | EPHX2 (0.42) | DDR1RIPK1HSD11B1 | |
| SCHEMBL7366762 | 0.78 | RIPK1 (0.50) | DDR1RIPK1 | |
| SCHEMBL7367345 | 0.74 | DDR1 (0.40) | DDR1RIPK1 | |
| SCHEMBL7367627 | 0.74 | LMNA (0.43) | DDR1RIPK1 | |
| SCHEMBL10179924 | 0.70 | CTSB (0.53) | DDR1HSD11B1 | |
| SCHEMBL8684987 | 0.70 | CES1 (0.46) | RIPK1 | |
| SCHEMBL19617799 | 0.69 | PSIP1 (0.45) | DDR1HSD11B1 | |
| SCHEMBL167924 | 0.68 | MMP2 (0.57) | — | |
| SCHEMBL28247232 | 0.67 | MMP2 (0.41) | HSD11B1 | |
| SCHEMBL8253718 | 0.66 | DDR1 (0.50) | DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259506-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6387911-B1 | Pyrazinone thrombin inhibitors | MERCK & CO., INC. | 2002-05-14 | — | — | US | disclosed |
| WO-2001038323-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2001-05-31 | — | — | WO | disclosed |