Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10068052 | 0.90 | NEK2 (0.38) | NEK2TSHRCYP2D6USP2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL25351354 | 0.87 | NEK2 (0.37) | NEK2TSHRCYP2D6USP2ALDH1A1 | |
| SCHEMBL287483 | 0.81 | ESR2 (0.34) | — | |
| Oxalic Acid SCHEMBL30335525 | 0.79 | CYP1A2 (0.36) | NEK2TSHRCYP2D6USP2CYP3A4 | |
| SCHEMBL4450929 | 0.78 | NEK2 (0.34) | NEK2TSHRCYP2D6USP2ALDH1A1 | |
| SCHEMBL25726486 | 0.78 | NEK2 (0.34) | NEK2TSHRCYP2D6USP2ALDH1A1 | |
| SCHEMBL2527186 | 0.77 | NEK2 (0.41) | NEK2TSHRCYP2D6USP2ALDH1A1 | |
| SCHEMBL30690319 | 0.76 | ALDH1A1 (0.31) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5249983 | 0.76 | NEK2 (0.33) | NEK2TSHR | |
| SCHEMBL486771 | 0.76 | ESR2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111868033-B | Herbicidal 3-azaspiro [5.5] undecane-8, 10-dione compounds | 先正达参股股份有限公司 | 2024-01-30 | — | — | CN | disclosed |
| CN-111868033-B | Herbicidal 3-azaspiro [5.5] undecane-8, 10-dione compounds | 先正达参股股份有限公司 | 2024-01-30 | — | — | CN | disclosed |
| US-11542235-B2 | Herbicidal 3-azaspiro[5.5] undecane-8, 10-dione compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2023-01-03 | — | — | US | disclosed |
| US-20220117228-A1 | SUBSTITUTED AZASPIRO-CYCLES AS HERBICIDES | SYNGENTA CROP PROTECTION AG (CH) | 2022-04-21 | — | — | US | disclosed |
| EP-3752490-B1 | HERBICIDAL 3-AZASPIRO[5.5]UNDECANE-8,10-DIONE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2021-12-15 | — | — | EP | disclosed |
| EP-3752490-A1 | HERBICIDAL 3-AZASPIRO[5.5]UNDECANE-8,10-DIONE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2020-12-23 | — | — | EP | disclosed |
| EP-3752490-A1 | HERBICIDAL 3-AZASPIRO[5.5]UNDECANE-8,10-DIONE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2020-12-23 | — | — | EP | disclosed |
| WO-2019158666-A1 | HERBICIDAL 3-AZASPIRO[5.5]UNDECANE-8,10-DIONE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2019-08-22 | — | — | WO | disclosed |
| WO-2019158666-A1 | HERBICIDAL 3-AZASPIRO[5.5]UNDECANE-8,10-DIONE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2019-08-22 | — | — | WO | disclosed |
| EP-0854869-A1 | SPIRO COMPOUNDS AS INHIBITORS OF FIBRINOGEN-DEPENDENT PLATELET AGGREGATION | ELI LILLY AND COMPANY (US) | 1998-07-29 | — | — | EP | disclosed |
| WO-1997011940-A1 | SPIRO COMPOUNDS AS INHIBITORS OF FIBRINOGEN-DEPENDENT PLATELET AGGREGATION | ELI LILLY AND COMPANY (US) | 1997-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11542235-B2 | Herbicidal 3-azaspiro[5.5] undecane-8, 10-dione compounds | DDT, DECR1, DHRS9 | NEK2 2834/4885TSHR 1601/4885CYP2D6 669/4885 |
| US-20220117228-A1 | SUBSTITUTED AZASPIRO-CYCLES AS HERBICIDES | DDT, DHFR, CCNB3 | NEK2 3015/4885TSHR 1160/4885CYP2D6 240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.