Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.47 |
| ▸ | HTR2A | P28223 | 11/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365322 | 0.88 | HTR2A (0.48) | DRD2HTR2AHTR7HTR1AKCNH2 | |
| SCHEMBL8113107 | 0.77 | HTR2A (0.60) | DRD2HTR2AHTR7HTR1AKCNH2 | |
| SCHEMBL7368733 | 0.76 | DRD2 (0.53) | DRD2HTR2AHTR7HTR1AKCNH2 | |
| SCHEMBL13448255 | 0.76 | HTR2A (0.60) | DRD2HTR2AHTR7HTR1AKCNH2 | |
| SCHEMBL22302778 | 0.72 | DRD2 (0.63) | DRD2HTR2AHTR7HTR1AKCNH2 | |
| SCHEMBL7367433 | 0.72 | DRD2 (0.55) | DRD2HTR2AHTR7KCNH2SLC6A4 | |
| SCHEMBL7365706 | 0.72 | DRD2 (0.55) | DRD2HTR2AHTR7KCNH2SLC6A4 | |
| SCHEMBL7360772 | 0.70 | DRD2 (0.53) | DRD2HTR2AHTR1ASLC6A4HTR2C | |
| SCHEMBL531012 | 0.69 | ACHE (0.52) | DRD2HTR2AHTR7HTR1AKCNH2 | |
| SCHEMBL7370354 | 0.69 | DRD2 (0.52) | DRD2HTR2AHTR7KCNH2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780474-A | ADMINISTERING IN THE TREATMENT OF PSYCHOTIC DISORDERS, ANXIO-DEPRESSIVE DISORDERS AND AGGRESSIVENESS | ADIR ET COMPAGNIE (FR) | 1998-07-14 | — | — | US | claimed |
| US-5780474-A | ADMINISTERING IN THE TREATMENT OF PSYCHOTIC DISORDERS, ANXIO-DEPRESSIVE DISORDERS AND AGGRESSIVENESS | ADIR ET COMPAGNIE (FR) | 1998-07-14 | — | — | US | disclosed |