Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 8/20 | 0.48 |
| ▸ | HTR2A | P28223 | 7/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14128737 | 0.98 | ACHE (0.51) | ACHEDRD2HTR2AHTR7HTR1A | |
| SCHEMBL6218345 | 0.85 | DRD2 (0.47) | ACHEDRD2HTR2AHTR7HTR1A | |
| Hydrochloric Acid SCHEMBL6248461 | 0.84 | DRD2 (0.46) | ACHEDRD2HTR2AHTR7HTR1A | |
| SCHEMBL13448255 | 0.81 | HTR2A (0.60) | ACHEDRD2HTR2AHTR7HTR1A | |
| SCHEMBL9035904 | 0.81 | MAT2A (0.48) | HTR2AHTR1AMAPK13CHRNA7HTR3A | |
| SCHEMBL5905921 | 0.81 | MAPK13 (0.43) | ACHEMAPK13ALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL9037461 | 0.80 | MAT2A (0.47) | HTR2AHTR1AMAPK13CHRNA7HTR3A | |
| SCHEMBL22302778 | 0.79 | DRD2 (0.63) | ACHEDRD2HTR2AHTR7HTR1A | |
| SCHEMBL2540344 | 0.78 | DRD2 (0.44) | ACHEDRD2HTR2AHTR7HTR1A | |
| SCHEMBL2540345 | 0.77 | HTR2A (0.45) | ACHEDRD2HTR2AHTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454256-B1 | Process for the synthesis of paliperidone | KRKA D D NOVO MESTO (SI) | 2015-09-16 | — | — | EP | claimed |
| EP-2275423-B9 | Process for the synthesis of paliperidone | KRKA D D NOVO MESTO (SI) | 2012-08-15 | — | — | EP | claimed |
| US-20120165527-A1 | PROCESS FOR THE PREPARATION OF PURE PALIPERIDONE | ORCHID CHEMICALS & PHARMACEUTICALS LTD. (IN) | 2012-06-28 | — | — | US | claimed |
| EP-2454256-A1 | PROCESS FOR THE SYNTHESIS OF PALIPERIDONE | KRKA, D.D., Novo Mesto (SI) | 2012-05-23 | — | — | EP | claimed |
| WO-2012042368-A1 | PROCESS FOR PREPARATION OF PALIPERIDONE | AUROBINDO PHARMA LIMITED (IN) | 2012-04-05 | — | — | WO | claimed |
| EP-2275423-B1 | Process for the synthesis of paliperidone | KRKA (SI) | 2012-02-08 | — | — | EP | claimed |
| WO-2011073997-A2 | PROCESS FOR PREPARING PALIPERIDONE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | CADILA HEALTHCARE LIMITED (IN) | 2011-06-23 | — | — | WO | claimed |
| US-20110087024-A1 | PROCESS FOR THE PREPARATION OF PALIPERIDONE INTERMEDIATES | GLENMARK HOUSE (IN) | 2011-04-14 | — | — | US | claimed |
| EP-2285804-A2 | A PROCESS FOR THE PREPARATION OF PALIPERIDONE INTERMEDIATES | Glenmark Generics Limited (IN) | 2011-02-23 | — | — | EP | claimed |
| WO-2011006638-A1 | PROCESS FOR THE SYNTHESIS OF PALIPERIDONE | KRKA, D.D., NOVO MESTO (SI) | 2011-01-20 | — | — | WO | claimed |
| WO-2009045489-A2 | PROCESS FOR THE SYNTHESIS OF CMHTP, A PALIPERIDONE INTERMEDIATE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-04-09 | — | — | WO | claimed |
| WO-2008140646-A2 | PROCESS FOR THE SYNTHESIS OF CMHTP AND INTERMEDIATES THEREOF | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-11-20 | — | — | WO | claimed |
| US-20080214809-A1 | Process for the synthesis of CMHTP and intermediates thereof | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-09-04 | — | — | US | claimed |
| US-20080200676-A1 | Process for the synthesis of CMHTP and intermediates thereof | TEVA PHARMACEUTICALS USA, INC. | 2008-08-21 | — | — | US | claimed |
| EP-1945640-A2 | PROCESS FOR THE SYNTHESIS OF 9-HYDROXY RISPERIDONE (PALIPERIDONE) | Teva Pharmaceutical Industries Ltd. (IL) | 2008-07-23 | — | — | EP | claimed |
| US-20080171875-A1 | Process for the synthesis of 9-hydroxy risperidone (paliperidone) | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-07-17 | — | — | US | claimed |
| EP-1924583-A2 | PROCESS FOR THE SYNTHESIS OF CMHTP AND INTERMEDIATES THEREOF | Teva Pharmaceutical Industries Ltd. (IL) | 2008-05-28 | — | — | EP | claimed |
| WO-2008024415-A2 | PROCESS FOR THE SYNTHESIS OF CMHTP AND INTERMEDIATES THEREOF | TEVA PHARMACEUTICAL INSUSTRIES LTD. (IL) | 2008-02-28 | — | — | WO | claimed |
| WO-2008021345-A2 | PROCESS FOR THE SYNTHESIS OF 9-HYDROXY RISPERIDONE (PALIPERIDONE) | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-02-21 | — | — | WO | claimed |
| CN-1531432-A | New use of iloperidone | ��˹��ŵ�� | 2004-09-22 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165527-A1 | PROCESS FOR THE PREPARATION OF PURE PALIPERIDONE | FIP1L1, DHPS, CYP2D6 | ACHE 4831/4885DRD2 500/4885HTR2A 282/4885 |
| US-20080214809-A1 | Process for the synthesis of CMHTP and intermediates thereof | HAMP, TPMT, MPHOSPH6 | ACHE 3785/4885DRD2 644/4885HTR2A 29/4885 |
| US-20080200676-A1 | Process for the synthesis of CMHTP and intermediates thereof | HAMP, DHPS, MPHOSPH6 | ACHE 4286/4885DRD2 930/4885HTR2A 27/4885 |
| US-20080171875-A1 | Process for the synthesis of 9-hydroxy risperidone (paliperidone) | HTR3C, HTR1A, HTR6 | ACHE 4222/4885DRD2 30/4885HTR2A 11/4885 |
| US-20110087024-A1 | PROCESS FOR THE PREPARATION OF PALIPERIDONE INTERMEDIATES | DHPS, AVPR2, CYP2D6 | ACHE 4808/4885DRD2 178/4885HTR2A 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.