Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 14/20 | 0.60 |
| ▸ | MMP3 | P08254 | 14/20 | 0.60 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.55 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.55 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.53 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.53 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.51 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.50 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422973 | 0.94 | MMP2 (0.67) | MMP2MMP3SLC1A2SLC1A1 | |
| SCHEMBL7422976 | 0.94 | MMP2 (0.67) | MMP2MMP3SLC1A2SLC1A1 | |
| SCHEMBL27541801 | 0.92 | S1PR2 (0.55) | MMP2MMP3GRIK1GRIK2SLC1A2 | |
| SCHEMBL21895810 | 0.89 | MMP2 (0.61) | MMP2MMP3S1PR2S1PR1 | |
| SCHEMBL7478270 | 0.88 | MMP2 (0.54) | MMP2MMP3GRIK1GRIK2SLC1A2 | |
| SCHEMBL7382744 | 0.88 | MMP2 (0.55) | MMP2MMP3GRIK1S1PR2S1PR1 | |
| SCHEMBL7362919 | 0.88 | MMP2 (0.55) | MMP2MMP3GRIK1S1PR2S1PR1 | |
| SCHEMBL5699299 | 0.86 | ALDH1A1 (0.57) | MMP2MMP3GRIK1GRIK2SLC1A2 | |
| SCHEMBL5699267 | 0.86 | ALDH1A1 (0.57) | MMP2MMP3GRIK1GRIK2SLC1A2 | |
| SCHEMBL8905851 | 0.86 | MMP2 (0.55) | MMP2MMP3GRIK1GRIK2S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028716-A1 | METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION | WARNER-LAMBERT COMPANY (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1998025597-A2 | METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION | WARNER-LAMBERT COMPANY (US) | 1998-06-18 | — | — | WO | disclosed |